Retrograde Endoscopic Delivery of Botulinum Toxin for Anal Fissures

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Botulinum toxin treatment for anal fissure.

OBJECTIVES To evaluate the effectiveness of Botulinum toxin injection in the treatment of anal fissure. METHODS 38 patients (22 males, 16 females; mean age (SD) of 33.3 (8.3) years) who have presented to Surgical Outpatient Clinic at Al Ain Hospital, United Arab Emirates, with anal fissure in the period between June 2000 and September 2001 and treated with Botulinum toxin injection were retro...

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Botulinum toxin for chronic anal fissure.

Botulinum toxin can chemically denervate striated muscle. Botulinum toxin A (15 U) was used to treat ten patients with chronic anal fissure by injection in the internal sphincter. In seven patients, the lesion healed at 2 months after treatment; one relapsed at 3 months. In one patient the lesion healed at 1 month, but partly relapsed a month later. Mild faecal incontinence lasting for 1 day wa...

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Botulinum toxin A injection for chronic anal fissures and anal sphincter spasm improves quality of life in recessive dystrophic epidermolysis bullosa

We report a 20-year-old female with generalized, severe, recessive dystrophic epidermolysis bullosa who developed secondary chronic anal fissures. This resulted in anal sphincter spasm and severe, disabling pain. She was treated with five botulinum toxin A injections into the internal anal sphincter over a period of 2 years and gained marked improvement in her symptoms. This case demonstrates t...

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Gastric peroral endoscopic myotomy for gastroparesis, after botulinum toxin injection.

A 45-year-old woman had refractory Epstein–Barr virus-associated gastroparesis. Despite lifestyle modification and medication therapy, the patient had recurrent hospitalizations for gastroparesis. Management also included four previous sessions of endoscopic botulinum toxin injection. Despite transient symptomatic improvement, the patient’s symptoms had recurred. She was not a candidate for sur...

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Anal fissures; first do no harm.

emergency centre staffed with GPs, nurse practitioners, and emergency medicine doctors. Handover between OOH and in-hours GPs has been defined as ‘one of the most perilous procedures in medicine, and when carried out improperly can be a major contributory factor to subsequent error and harm to patients’.1 In-hours care accounts for 50 hours/week while OOH care accounts for 118 hours/week. Hando...

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ژورنال

عنوان ژورنال: Endoscopy

سال: 2006

ISSN: 0013-726X,1438-8812

DOI: 10.1055/s-2006-944583